Carbamoyl phosphate synthetase I deficiency
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| Carbamoyl phosphate synthetase I deficiency | |
|---|---|
| Other names | CPS I deficiency |
| Specialty | Medical genetics |
Carbamoyl phosphate synthetase I deficiency (CPS I deficiency)[1] is an autosomal recessive metabolic disorder that causes ammonia to accumulate in the blood due to a lack of the enzyme carbamoyl phosphate synthetase I. Ammonia, which is formed when proteins are broken down in the body, is toxic if the levels become too high. The nervous system is especially sensitive to the effects of excess ammonia.
Signs and symptoms
[edit]Carbamoyl phosphate synthetase I deficiency often becomes evident in the first few days of life.[2] An infant with this condition may be lacking in energy (lethargic) or unwilling to eat, and have a poorly controlled breathing rate or body temperature.[2] Some babies with this disorder may experience seizures or unusual body movements, or go into a coma.[2] Complications of carbamoyl phosphate synthetase I deficiency may include developmental delay and mental retardation.
In some affected individuals, signs and symptoms of carbamoyl phosphate synthetase I deficiency may be less severe, and may not appear until later in life.
Genetics
[edit]
CPS I deficiency is inherited in an autosomal recessive manner.[1] This means the defective gene responsible for the disorder is located on an autosome, and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder. The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene, but usually do not experience any signs or symptoms of the disorder.
Pathophysiology
[edit]Mutations in the CPS1 gene cause carbamoyl phosphate synthetase I deficiency. Carbamoyl phosphate synthetase I deficiency belongs to a class of genetic diseases called urea cycle disorders. The urea cycle is a sequence of reactions that occurs in liver cells. This cycle processes excess nitrogen, generated when protein is used by the body, to make a compound called urea that is excreted by the kidneys.
In carbamoyl phosphate synthetase I deficiency, the enzyme that regulates the urea cycle is damaged or missing. The urea cycle cannot proceed normally, and nitrogen accumulates in the bloodstream in the form of ammonia. Ammonia is especially damaging to the nervous system, and excess ammonia causes neurological problems and other signs and symptoms of carbamoyl phosphate synthetase I deficiency.
Diagnosis
[edit]Prenatal diagnosis can occur through fetal liver biopsy or by using genomic DNA from amniotic fluid. [3]
Treatment
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Depending on clinical status and the blood ammonia level, the logical first step is to reduce protein intake and to attempt to maintain energy intake. Initiate intravenous infusion of 10% glucose (or higher, if administered through a central line) and lipids. Intravenous sodium benzoate and sodium phenylacetate may be helpful. Arginine is usually administered with benzoate and phenylacetate. This is best administered in the setting of a major medical center where facilities for hemodialysis in infants is available. Glycerol phenylbutyrate is a pre-prodrug that undergoes metabolism to form phenylacetate. Results of a phase 3 study comparing ammonia control in adults showed glycerol phenylbutyrate was noninferior to sodium phenylbutyrate. In a separate study involving young children ages 2 months through 5 years, glycerol phenylbutyrate resulted in a more evenly distributed urinary output of PAGN over 24 hours and accounted for fewer symptoms from accumulation of phenylacetate. In patients with an extremely high blood ammonia level, rapid treatment with hemodialysis is indicated. Metabolic disease specialists should provide long-term care with very close and frequent follow-up.
References
[edit]- ^ a b Online Mendelian Inheritance in Man (OMIM): 237300
- ^ a b c "Carbamoyl-phosphate synthetase 1 deficiency". Genetic and Rare Diseases Information Center. National Center for Advancing Translational Sciences, National Institutes of Health. February 2023. Retrieved 26 October 2023.
- ^ Aoshima, Tsutomu; Kajita, Mitsuharu; Sekido, Yoshitaka; Mimura, Shunji; Itakura, Atsuo; Yasuda, Izumi; Saheki, Takeyori; Watanabe, Kazuyoshi; Shimokata, Kaoru; Niwa, Toshimitsu (2001). "Carbamoyl phosphate synthetase I deficiency: molecular genetic findings and prenatal diagnosis". Prenatal Diagnosis. 21 (8). Wiley: 634–637. doi:10.1002/pd.123. ISSN 0197-3851. PMID 11536261. S2CID 30688532.
External links
[edit]- GeneReviews/NCBI/NIH/UW entry on Urea Cycle Disorders Overview
- Carbamoyl phosphate synthetase I deficiency at NLM Genetics Home Reference